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mitotane will minimize the level or effect of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers cuts down plasma concentration of abemaciclib and its metabolites.Cell proliferation was assessed using a bromodeoxyuridine (BrdU) proli